Changes of endothelial function and its relation with restenosis in patients performed carotid artery stenting
10.3760/cma.j.issn.1671-8925.2011.05.006
- VernacularTitle:颈动脉支架置入术后内皮功能的变化及与再狭窄的相关研究
- Author:
Zhang-Yong XIA
1
;
Hua YANG
;
Huai-Qian QU
;
Ke-Mi CUI
;
Wei-Dong CHENG
Author Information
1. 山东省聊城市人民医院
- Keywords:
Carotid stenosis;
Stent;
Von willebrand;
Endothelin-1
- From:
Chinese Journal of Neuromedicine
2011;10(5):452-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of levels of von willebrand (vWF) and endothelin-1 (ET-1) and their relations with restenosis in patients performed carotid artery stenting (CAS).Methods The levels of vWF and ET-1 in 67 patients were measured before CAS and 1 h, 2 w, 1 and 6months, and 1 y after the stenting. All the patients were divided into restenosis group and non-restenosis group according to the examining results of cervical CTA 1 y after CAS. Results In the follow-up survey, 1 patient was died and 4 were out of touch. Fourteen patients had restenosis of different degrees;the restenosis rates of 3 patients was more than 50 percent. The level of vWF 1 h and 6 months after CAS and the level of ET-1 1 h, 2 w and 6 months after CAS were increased rapidly as compared with those before CAS (P<0.05). As compared with those in the on-restenosis group, the level of vWF 1 h, 2 w and 6 months after CAS and the level of ET-1 1 h, 2 w, 1 and 6 months after CAS in the restenosis group were obviously increased (P<0.05). Conclusion The levels of vWF and ET-1 increase continually in a short term (within 2 weeks) after CAS, and increase once again 6 months after CAS which increases the risk of restenosis.Monitoring the levels of vWF and ET-1 may be of great value in judging long-term prognosis.
