Pituitary stalk interruption syndrome: a report of 9 cases
10.3760/cma.j.issn.1671-8925.2011.04.022
- VernacularTitle:垂体柄中断综合征九例报道
- Author:
Zhuo-Na YIN
1
;
Wen-Sheng JIN
;
Wei-Guo XU
;
Li-Xin HAN
Author Information
1. 广州军区广州总医院
- Keywords:
Growth hormone;
Hypopituitarism;
Pituitary stalk;
Puberty,delayed
- From:
Chinese Journal of Neuromedicine
2011;10(4):413-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of pituitary stalk interruption syndrome (PSIS) to raise our awareness of this disease. Methods The clinical data, including clinical manifestations, MR image changes and disorders of endocrine system, of 9 patients admitted to our hospital were collected and analyzed. Results Eight of 9 patients showed absence of pituitary stalk under MRI with height of the pituitary no more than 3 mm; only one exceptional patient with traumatic etiology showed 4.5 mm of the pituitary. Two patients were adult-onset and clearly induced by head trauma, and both of them were hospitalized due to pituitary crisis; the other 7 patients, having the disease at the age of 5 to 12, were complained of growth and development retardation at the age of 17 to 28. All the patients were totally deficient in growth hormone (GH) and pituitary gonadotropin (GnH) secretion; in addition, secondary hypothyroidism and hypocortisolism occurred in 6 of the 7 young-onset patients. No consanguinity, sign of pituitary crisis, and septooptic dysplasia were noted in those young-onset patients.Conclusion PSIS is characterized by absence of pituitary stalk and pituitary hypoplasia, by GH and GnH deficiency, and mostly combined with ACTH and TSH deficiency of different extent.
