Relationship between D-wave of the spinal motor evoked potential and hindlimb motor function status of rabbits with experimental spinal cord injury
10.3760/cma.j.issn.1671-8925.2011.04.016
- VernacularTitle:兔脊髓损伤后脊髓运动诱发电位D波与后肢运动功能的关系
- Author:
Zhi-Qi MAO
1
;
Yong-Jian LU
;
Ze-Lu FANG
Author Information
1. 首都医科大学宣武医院
- Keywords:
Spinal cord injury;
D-wave;
Myodynamia
- From:
Chinese Journal of Neuromedicine
2011;10(4):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between D-wave of thc spinal motor evoked potential and hindlimb motor function status (myodynamia) of rabbits with experimental spinal cord injury. Methods Forty-five rabbits were randomly divided into a control group and 8 injured groups (receiving Allen's injury of50, 75, 100, 125, 150, 175, 200 and 250 gcf, respectively). The myodynamia of hindlimbs and the latency and amplitude of D-wave of the spinal motor evoked potential were recorded right after the injury and in the 4th week of injury, respectively. Simultaneously in the 4th week of injury,the rabbits' spinal sections were stained with neurofilament (NF) immunohistochemistry and their pathological morphologies were observed; and optical densities of NF were measured. Statistic analysis of correlation between myodynamia of hindlimbs and latency and amplitude of D-wave was performed.Results A statistic linear correlation was found between amplitudes declination of D-wave of the spinal motor evoked potential and modified Tarlov's scores right after the injury and in the 4th week of injury (R2=0.98, P＜0.00, regression curve: Y=0.33+4.82X; R=0.99, P＜0.001, regression curve: Y=0.04+0.5 1X),but no statistical correlation was noted between myodynamia and the latency of D-wave of the spinal motor evoked potential at the same time periods(R2=-0.097, P=0.573; R2=-0.165, P=0.337). And the optical density of NF decreased following the amplitude declination of D-wave of the spinal motor evoked potential with linear correlation (R2=0.87, P＜0.001, regression curve: Y= 0.12+0.58X).Conclusion Amplitude declination of D-wave of the spinal motor evoked potential could be used to evaluate the severity of dyskinesia in the injured spinal cord.
