Effect of antiepileptic drugs on prevention of epilepsy after craniocerebral injury: a Meta-analysis
10.3760/cma.j.issn.1671-8925.2011.04.006
- VernacularTitle:颅脑损伤后预防应用抗癫痫药物疗效Meta分析
- Author:
Ce ZHANG
1
;
Qing FAN
;
Jian YIN
;
Gui-Ru LI
;
Hui-Yi LV
;
Ning ZHANG
;
Guang-Jun FAN
;
Tang-Na HAO
;
Xiao-Yan LUO
;
Ting-Yu LI
Author Information
1. 大连医科大学附属第二医院
- Keywords:
Craniocerebral injury;
Epilepsy;
Anti-epileptic drug;
Meta analysis
- From:
Chinese Journal of Neuromedicine
2011;10(4):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the efficacy ofantiepileptic drugs (AEDs) on prevention of epilepsy after craniocerebral injury. Methods Related articles searched from the databases such as PubMed, Ovid, Springer, VP and CNKI were collected and strictly evaluated; 21 articles were finally selected. Whether pretreatment with AEDs played its role in epilepsy appeared in the early/late stages was discussed with Meta-analysis; the influences of different craniocerebral injury types (resulting from trauma or surgery) on the efficacy of anti-epilepsy prophylaxis, and the mortality rate of the patients performed pretreatment were analyzed with Meta-analysis. Results Pretreatment withAEDs could significantly improve the results (OR=0.66, Z=4.31, P=0.000); pretreatment with AEDs obviously decreased the rate of epilepsy appeared in the early stage (OR=0.48, Z=3.980, P=0.000), but did not statistically decrease the rate of epilepsy appeared in the late stage (OR=1.05, Z=0.310, P=0.760);pretreatment with diphenylhydantoin (OR=0.53) was more effective on epilepsy appeared in the early stage than pretreatment with carbamazepine (OR=0.40). Pretreatment with AEDs was all-effective considering different craniocerebral injury types resulting from trauma (OR=0.48) and surgery (OR=0.69). No significant differences were noted on the mortality rate of patients performed pretreatment and without pretreatment (OR=0.82, Z=0.920, P=0.360). Conclusion The inception rate of epilepsy can be decreased remarkably after anti-epilepsy prophylaxis with AEDs in patients after craniocerebral injury,and diphenylhydantoin has a better effect for epilepsy appeared in the early stage. No reasonable differences between various kinds of AEDs on epilepsy appeared in the late stage are noted. Pretreatment with AEDs enjoys a good result in both post-traumatic brain injury and craniotomy. Pretreatment can not affect the mortality rate of the patients.
