Double-blind, placebo-controlled, randomized, multicenter studies of oxiracetam in the treatment of brain injury
10.3760/cma.j.issn.1671-8925.2011.02.019
- VernacularTitle:注射用奥拉西坦治疗颅脑损伤的随机、双盲、对照、多中心临床研究
- Author:
Cheng-Yi LUO
1
;
Yi-Quan KE
;
Ru-Xiang XU
;
Xiang ZHANG
;
Jian-Wen GU
;
Ru-Tong YU
;
Sui-Ruan WANG
;
Zhi-Gang WANG
;
Kai-Xuan LU
;
Shun WAN
Author Information
1. 南方医科大学珠江医院
- Keywords:
Craniocerebral injury;
Neurological deficit;
Oxiracetam;
Randomized controlled trials;
Double-blind method;
Multi-center studies
- From:
Chinese Journal of Neuromedicine
2011;10(2):192-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of oxiracetam in the treatment of neurological deficits resulting from brain injury through the comparison of oxiracetam for injection and piracetam for injection in clinical trials. Methods A multiple-center, randomized, double-blind,parallel study was performed on 239 patients; these patients were divided into experimental group (oxiracetam for injection, n=120) and control group (piracetam, n=119). National institutes of health stroke scale (NIHSS), Glasgow coma scale (GCS), myodynamia grading, mini-metal state examination (MMSE) were employed to evaluate the therapeutic effects; electrocardiogram and laboratory examination were performed, and the side effects were also observed. Results The scores of NIHSS,GCS and myodynamia grading after treatment in the 2 groups were all significantly higher than those before treatment (P＜0.05); however, no significant differences on these scores were noted between the experimental group and control group (P＞0.05). No serious adverse events were noted in both groups.Conclusion Oxiracetam, the same as piracetam, is safe and effective in the treatment of neurological deficits secondary to brain injury.
