Characteristics of EEG and neuropathology of acute morphine dependent cats
10.3760/cma.j.issn.1671-8925.2011.02.006
- VernacularTitle:吗啡急性成瘾猫脑电图及神经病理特点
- Author:
Tao GUO
1
;
Jin-Sheng KANG
;
Jie ZHENG
;
Chang-Zheng DONG
;
Xiang-Yong YUE
;
Wen-Ling LI
;
Wen-Qing ZHAO
Author Information
1. 河北省人民医院
- Keywords:
Morphine dependence;
EEG;
Pathological change
- From:
Chinese Journal of Neuromedicine
2011;10(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the cat models of acute morphine dependence, and explore the etiopathogenesis by investigating its electrophysiology and pathology changes of its brain tissue to provide pathological and electrophysiological evidences for clinical treatment. Methods Twelve cats were randomly divided into control group (n=3) and morphine dependent group (n=9); cats in the morphine dependent group were induced by injection of morphine hydrochloride in a daily increased manner, and at the same time, cats in the control group were injected physiological saline. After the success of model making, EEG was performed on the cortex, hippocampus and nucleus accumbens in cats of the 2 groups; the changes of every encephalic region and pituitary gland were observed under light microscope and electron microscope. Results Morphine dependent cat models were successfully established. EEG indicated that physiological waves decreased and pathological waves appeared frequently in cats of the morphine dependent group as compared with those in the normal ones.Physiological examinations showed that the neuronal degeneration, organelle reduction, mitochondria swelling, chromatin margination and karyopycnosis or even nuclear necrosis occurred in the cortex of every encephalic region. Conclusion Pathological changes and brain damages will appear under EEG after long-term use of morphine, which is intimately related to neuron ultramicrostructure changes.
