Lecithin-cholesterol acyltransferase gene 511C/T polymorphism is associated with cerebral hemorrhage
10.3760/cma.j.issn.1671-8925.2011.02.003
- VernacularTitle:卵磷脂胆固醇酰基转移酶基因511C/T多态性与脑出血的关联研究
- Author:
Rong-Yao HOU
1
;
Xiao-Yan ZHU
;
Rui-You GUO
;
Hong-Wei XU
;
Bo XIAO
;
Qi-Dong YANG
;
Bei-Sha TANG
Author Information
1. 青岛大学医学院附属海慈医院
- Keywords:
Lecithin;
cholesterol acyltransferase;
Cerebral hemorrhage;
Polymorphism,single nucleotide;
High-density lipoprotein cholesterol
- From:
Chinese Journal of Neuromedicine
2011;10(2):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution of lecithin cholesterol acyltransferase (LCAT)gene 511C/T polymorphism in Chinese Han population and the association of its polymorphism with the occurrence of cerebral hemorrhage (CH). Methods The LCAT gene 511C/T polymorphism was identified by PCR, single-strand conformation polymorphism (SSCP) and DNA sequencing in 150 patients with CH and 122 age- and gender-matched healthy controls. Results The 511 situs of the fourth extron in LCAT gene existed polymorphism; C/T in this situs of both groups satisfied Hardy-Weinberg equilibrium. The CT genotype frequency (3.3%) and T allele frequency (1.7%) in patient group were not significantly higher than those (1.6%, 0.8%, respectively) in controls (P＞0.05).The level of high-density lipoprotein cholesterol (HDL-C) in 511CC subgroup ([1.44±0.42] mmol/L) was significantly higher than that in 511CT subgroup ([1.06±0.30] mmol/L) of patient group (P＜0.05).Conclusion The LCAT gene 511C/T polymorphism is not possibly a predisposing factor of CH in Chinese Han population. T allele frequency might be connected with the metabolism of HDL-C.
