Value of 2-18F-2-deoxy-β-D-glucose PET/CT in tumor detection of patients suspected as having paraneoplastic syndromes
10.3760/cma.j.issn.1671-8925.2011.01.022
- VernacularTitle:18F-FDG PET/CT检测神经系统副肿瘤综合征疑似患者恶性肿瘤的应用价值
- Author:
Zhi-Wei GUAN
1
;
Bai-Xuan XU
;
Rui-Ming WANG
;
Da-Yi YIN
;
Jia-He TIAN
Author Information
1. 解放军总医院
- Keywords:
Paraneoplastic syndrome;
Cerebral tumor;
18F-FDG
- From:
Chinese Journal of Neuromedicine
2011;10(1):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the value of 2-18F-2-deoxy-β-D-glucose (18F-FDG)PET/CT in malignancy tumor detection of patients suspected as having paraneoplastic syndrome (PNS).Methods The clinical data of 54 patients suspected as having PNS, underwent PET/CT study in our hospital fiom June 2007 to December 2009, were retrospectively analyzed. The efficacy of 18F-FDG PET/CT on positive detection rate, positive predictive value of malignant tumors and on the detection of malignant tumor markers were analyzed with the results of pathological findings and clinical data;whether the course of disease could affect these detection was also analyzed. Results Positive results of 18F-FDG PET/CT were noted in 17 patients (31.5%), and 13 of them were confirmed as malignant tumors with pathological results. The positive predictive value of 18F-FDG PET/CT was 76.5%. The durations of patients with malignancies were not different from those of patients without malignancies.PET/CT enjoyed a significantly higher efficacy rate in identifying malignant tumors in patients with elevated tumor markers than in patients with tumor markers in normal range (P＜0.05). Conclusion 18F-FDG PET/CT improves the tumor detection rate in PNS suspects, especially in patients enjoying elevated tumor markers.
