Functional connectivity of prefrontal cortex in chronic heroin addicts:a resting-state functional MRI study
10.3760/cma.j.issn.1671-8925.2011.01.019
- VernacularTitle:长期海洛因成瘾者前额叶功能连接的静息态fMRI研究
- Author:
Yin-Bao QI
1
;
Xian-Ming FU
;
Ruo-Bing QIAN
;
Xiang-Pin WEI
;
Chao-Shi NIU
;
Chang-Xin WANG
;
Fei-Yan ZENG
;
Ye-Han WANG
Author Information
1. 安徽医科大学附属省立医院
- Keywords:
Heroin addiction;
Prefrontal cortex;
Resting state functional MRI;
Functional connectivity
- From:
Chinese Journal of Neuromedicine
2011;10(1):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of functional connectivity of the prefrontal cortex in chronic heroin addicts under resting-state functional MRI (fMRI). Methods Resting fMRI examination was performed on 13 chronic heroin addicts and 14 healthy volunteers. After pre-processing the resting-state fMRI data, the prefrontal cortex was selected as the seed region, with which a whole-brain voxel temporal correlation in Iow frequency fMRI fluctuations was analyzed and the changes of functional connectivity of the prefrontal lobe in both chronic heroin addicts and healthy volunteers were calculated with SPM5 software. Results Compared with that in the control group, the functional connectivity between the left prefrontal cortex and the left hippocampus, right anterior cingulate, left middle frontal gyrus, right middle frontal gyrus, right precuneus in the heroin addiction group was significantly decreased. The functional connectivity between the right prefrontal cortex and the left orbital frontal cortex, left middle frontal gyrus in thc heroin addiction group was also significantly decreased as compared with that in the control group. Conclusion Functional connectivity of prefrontal cortex in chronic heroin addicts decreases, indicating that the prefrontal cortex may be involved in the maintenance of heroin addiction and relapse after withdrawal.
