Clinical analysis of diffuse axonal injury:a report of 280 cases

VernacularTitle:弥漫性轴索损伤280例临床分析
Author: Ping-Hua QIU ¹ ; Han HUANG ; Xi-Fen YAO ; Yu-Sheng WANG ; Peng-Fei WANG
Author Information

1. 广东省揭阳市人民医院
Keywords: Diffuse axonal injury; Brain injury; Treatment
From: Chinese Journal of Neuromedicine 2011;10(1):70-72
CountryChina
Language:Chinese
Abstract: Objective To discuss the clinical features and pathological changes of diffuse axonal injury (DAI), and explore the treatment and prognosis of patients with DAI. Methods Two hundred and eighty patients with DAI, admitted to our hospital from January 1999 to December 2009,were enrolled in our study; bilateral decompressive craniotomy was performed in 76 patients and conservative treatment in 204 patients; the clinical data and treatment efficacy of these patients were retrospectively analyzed. Results Good recovery was achieved in 122 patients (43.6%), mild disability in 86 (30.7%), severe disability in 37 (13.2%), persistent vegetative state in 2 (0.7%) and death in 33 (11.8%). Conclusion Decompressive craniotomy is needed as early as possible for patients with brain swelling, unilateral or bilateral mydriasis; early tracheotomy should be performed for patients in coma for a long time to maintain airway smooth; 20% mannitol plus furosemide plus albumin, together with methylprednisolone and mild hypothermia therapy, can be employed to treat patients with early dehydration.