Atypical extraventricular central neurocytoma: report of one case and literature review
10.3760/cma.j.issn.1671-8925.2010.12.026
- VernacularTitle:非典型性脑室外中枢神经细胞瘤一例报告及文献复习
- Author:
Hong-Bin NI
1
;
Wei-Bang LIANG
;
Jun WU
;
Wei JIN
;
Wu XU
Author Information
1. 南京大学医学院附属鼓楼医院
- Keywords:
Central neurocytoma;
Ventricle;
Diagnosis;
Treatment
- From:
Chinese Journal of Neuromedicine
2010;09(12):1279-1281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnosis and treatment of atypical extraventricular central neurocytoma. Methods We received 1 patient with atypical extraventricular central neurocytoma in January, 2010; the clinical and imaging manifestations, the pathologic features and microsurgical outcome were retrospectively analyzed; and the related literature was reviewed and compared. Results The lesions located at left frontal lobe, with clear boundaries to the brain tissue. Equal or slightly lower signals on MRI T1-weighted images (T1WI) and T2-weighted images (T2WI) was shown;inhomogeneous enhancement was noted on contrast-enhanced T1WI and T2WI. Meningioma was considered in the preoperative diagnosis. The tumor was grayish red and soft, and had general blood supply detected during the operation. Quick pathological diagnosis was made and it tended to be high-grade glioma. Immunohistochemistry indicated that the tumor cells were partly GFAP(+), S100(+)NeuN(+), Syn(+), Olig2(+), CgA(+), NSE(+) and NF(+), while those were EMA(-) and CD99(-); some P53 cells and about 10% Ki-67 cells were positive. These results prompted that these tumors having high proliferation index and atypical extraventricular neurocytoma was considered. Conclusion The imaging manifestation of EVN has certain features while immunohistochemistry is very important for its diagnosis. The best treatment is to perform microsurgery; the prognosis may be related to proliferation index of the tumor.
