Correlation of serum cystatin C and creatinine levels with cerebral infarction
10.3760/cma.j.issn.1671-8925.2010.12.012
- VernacularTitle:血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死相关性的研究
- Author:
Xiao-Qin WANG
1
;
Cun-Jie LIU
;
Ju-Yang ZHENG
;
Dong-Sheng FAN
Author Information
1. 华北煤炭医学院附属医院
- Keywords:
Cerebral infarction;
Cystatin C;
Creatinine
- From:
Chinese Journal of Neuromedicine
2010;09(12):1231-1233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum cystatin C and creatinine levels with cerebral infarction. Methods Eighty-four patients with cerebral infarction diagnosed by clinical manifestations, CT and (or) MRI and 76 healthy subjects were selected. Cystatin C level was tested by enzyme-linked immunosorbent assay (ELISA) and creatinine level was tested by the method of nitroxanthic acid. The correlation of cystatin C and creatinine levels with cerebral infarction was explored. Results The level of serum cystatin C in the cerebral infarction group (1.69±0.60 mg/L) was significantly lower as compared with that in the control group (2.00±0.67 mg/L) (t=-3.084, P=0.002); the level of serum creatinine in the cerebral infarction group (86.62±14.02 μmol/L) was significantly higher as compared with that in the control group (80.88±13.71 μmol/L) (t=2.611, P=0.010). Negative correlation between level of serum cystain C and cerebral infarction was noted (r=-0.238, P=0.002),while the level of serum creatinine was positively related to cerebral infarction (r=0.208, P=0.010).Conclusion A close correlation between cerebral infarction and both the levels of cystain C and creatinine exists, with cystatin C being a protective factor and creatinine being a risk factor for clinical cerebral infarction.
