Relationship between gene polymorphisms of thromboxane A2 receptor and cerebral infarction
10.3760/cma.j.issn.1671-8925.2010.12.011
- VernacularTitle:血栓素A2受体基因多态性与脑梗死的相关性研究
- Author:
Jing ZHAO
1
;
Lan ZHENG
;
Yi FU
;
Pei-Hua NI
;
Ying-Feng WENG
;
Huan-Yin LI
;
Jing-Shan SHAO
Author Information
1. 上海市闵行区中心医院
- Keywords:
Thromboxane A2 receptor;
Gene polymorphism;
Cerebral infarction
- From:
Chinese Journal of Neuromedicine
2010;09(12):1228-1230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the gene polymorphisms of thromboxane A2 receptor (TXA2R) and cerebral infarction. Methods A genetic association study of one single nucleotide polymorphism (rs768963) in the human TXA2R gene was performed in 334 patients with cerebral infarction and 135 healthy controls by polymerase chain reaction-amplification and restriction fragment length polymorphism(PCR-RFLP) method. Results The levels of blood pressure,blood-fat and serum glucose were independent risk factors for cerebral infarction. No significant differences in the overall distribution of genotypes (T/T, T/C and C/C) were noted (P＞0.05); however,significant differences in T or C gene frequency of rs768963 of TXA 2R gene between patients with cerebral infarction and noninfarction controls were found (P＜0.05). Logistic regression analysis showed that no association between the mutant of rs768963 of TXA 2R gene and such factors as gender, age and levels of blood fat, blood pressure and serum glucose was noted. Conclusion The rs768963 of TXA 2R gene in human thromboxane A2 receptor may be a risk factor for cerebral infarction and patients carried C allele are much likely to have cerebral infarction.
