Logistic regression analysis of the risk factors in progressive hemorrhagic injury after severe head injury
10.3760/cma.j.issn.1671-8925.2010.11.017
- VernacularTitle:中重型颅脑损伤后进展性出血性损伤危险因素的Logistic回归分析
- Author:
Guang FENG
1
;
Ji-Xin DUAN
;
Zhi-Jun ZHONG
;
Han-Chang YU
;
Ling HAN
;
Hui TANG
Author Information
1. 长沙市中医医院
- Keywords:
Craniocerebral trauma;
Progressive hemorrhagic injury;
Risk factor
- From:
Chinese Journal of Neuromedicine
2010;09(11):1150-1153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors related with progressive hemorrhagic injury (PHI)after severe head injury for a view to early diagnosis and treatment for this disease and providing a basis for effective prevention. Methods In a retrospective study of 262 patients with severe brain injury in considering the clinical data of the PHI, the occurrence is variable, and age, gender, bleeding site, type of bleeding, dilated pupils starus, level of systolic blood pressure on admission, time of CT for the first time,GOS scores, injured mechanism, interval between first and second time CT, application of high-dose mannitol, platelet (PLT) count, prothrombin time (PT), activated partial prothrombin time (APTT) were considered as independent variables. Results The incidence rate of having PHI was 47.7% (125/262);single-factor analysis revealed that, as compared with those in patients with non-PHI, 7 factors in patients with PHI were significantly different, namely, age, type of hemorrhage, interval between injury and first-time CT, GCS scores, PLT count, PT and APTT. Multivariate logistic regression analysis of the results showed that interval between injury and first-time CT, GCS scores, PLT count were the risk factors of having PHI, and their OR values were 3.5448, 3.2975 and 2.2361, respectively. Conclusion For patients with severe brain injury, the sooner the first time CT examination is performed, the lower the GCS scores are and the lower the PLT count is, the higher risk of having PHI is. Thus, dynamic CT formal review is suggested to improve the early diagnosis and treatment of PHI.
