Duration of untreated psychiatry affecting white matter integrity in first-episode medication-free patients with schizophrenia
10.3760/cma.j.issn.1671-8925.2010.11.011
- VernacularTitle:精神病未治疗期对首发未服药精神分裂症脑白质完整性的影响
- Author:
Qin-Ling WEI
1
;
Kang-Shun ZHU
;
Xiang-Lan WANG
;
Jin-Bei ZHANG
;
Zhuang KANG
;
Xiao-Feng GUO
;
Zi-Li HAN
;
Jing-Ping ZHAO
Author Information
1. 中山大学附属第三医院
- Keywords:
Schizophrenia;
Duration of untreated psychosis;
White matter;
Diffusion tensor imaging
- From:
Chinese Journal of Neuromedicine
2010;09(11):1125-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of duration of untreated psychiatry (DUP) on the white matter integrity in first-episode medication-free patients with schizophrenia. Methods The Chinese version of Nottingham Onset Schedule was used to assess the DUP of 39 first-episode medication-free patients with schizophrenia. According to the median of DUP, the 39 patients were grouped into long-DUP group and short-DUP group. Diffusion weighted images of the 39 patients' whole brains were acquired with a Half-Fourier Acquired Single-Shot Turbo Spin Echo (HASTE) sequence.After being preprocessed with DTI-studio and statistical parametric mapping software (SPM5), the fractional anisotropy (FA) images of the 2 groups were compared by two-sample t-test with SPM5 software. The differences of gender, age, education level and total scores of Positive and Negative Syndrome Scale (PANSS) scores between the 2 groups were also detected. Results No significant difference was noted on gender, age, education level, PANSS scores between the 2 groups (P＞0.05).Subjects of long-DUP group showed significantly reduced FA value in the right anterior cingulate fasciculus (x=8, y=40, z=24) and left prefrontal white matter thresholded (x=32, y=34, z=4) as compared with that of short-DUP group at a level of P＜0.001 (uncorrected). Conclusion Extension of the duration of DUP will reduce the white matter integrity in first-episode medication-free patients with schizophrenia.
