Effects of atorvastatin on levels of C-reactive protein and other inflammatory factors in patients with hypertension
10.3760/cma.j.issn.1671-8925.2010.11.007
- VernacularTitle:阿托伐他汀对高血压患者C反应蛋白及其他炎性因子的影响
- Author:
Jing WU
1
;
Gang WU
;
Mei-Ping WANG
;
Zhao-Min LIN
;
Zhi-Jian HU
Author Information
1. 福建省老年医院
- Keywords:
Lipids;
Antilipemic agent;
C-reactive protein;
Hypertension
- From:
Chinese Journal of Neuromedicine
2010;09(11):1108-1113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the effects of atorvastatin on high-sensitivity C-reactive protein (hs-CRP), yon willebrand factor (vWF), P-selectin, low-density lipoprotein-cholesterol (LDL-C)and carotid intima-media thickness (IMT) of patients with essential hypertension. Methods One hundred and fifty-one patients with mild hypertension were randomly divided into 3 groups: 10 mg atorvastatin, amlodipine and benazepril were daily delivered to group A (n=50); 20 mg atorvastatin,amlodipine and benazepril were daily delivered to group B (n=61); and amlodipine and benazepril were daily delivered to control group (n=40). All patients were assessed for the levels of hs-CRP, vWF,P-selectin, LDL-C and IMT at the baseline and every 3 months. The observation period lasted for 1 y and statistical analysis was performed on these collected data. Results As compared with that in the control group, significant reduction was identified on the levels of hs-CRP, vWF, P-selectin, LDL-C and IMT in group A and group B (P＜0.05). Correlation analysis discovered that the changes of levels of hs-CRP, VWF, P-selectin and IMT did not correlate with the reduction of LDL-C. Conclusion The progression of atherosclerosis can be delayed by atorvastatin in patients with hypertension, which is probably independent from its lipid-lowering function.
