Association between gene polymorphism of neuropeptide Y promoter and cerebral stroke subtypes according to TOAST criteria
10.3760/cma.j.issn.1671-8925.2010.10.017
- VernacularTitle:神经肽Y启动子基因多态性与脑梗死TOAST亚型相关性研究
- Author:
Si-Shan GAO
1
;
Lan TAN
;
Nan-Nan YU
;
Jin-Tai YU
;
Jing-Hui SONG
;
Teng MA
;
Nai-Dong WANG
Author Information
1. 青岛市黄岛中医院
- Keywords:
Neuropeptide Y;
Promoter;
Gene polymorphism;
Cerebral stroke;
Subtype according to TOAST criteria
- From:
Chinese Journal of Neuromedicine
2010;09(10):1037-1041
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between gene polymorphism of neuropeptide Y (NPY) promoter and cerebral stroke subtypes according to TOAST (Trail of ORG 10172 in Acute Stroke Treatment) criteria in Chinese Han population. Methods The gene polymorphisms at position of-399T/C, -883Tgins/del and -602G/T in NPY promoter were detected by PCR method and gene sequencing in 190 cases of large-artery atherosclerosis stroke (LAA), 260 cases of small-artery occlusion (SAO), 60 cases of cardioembolism stroke (CE), 29 cases of stroke of other demonstrated etiology (ODE),10 cases of stroke of other undemonstrated etiology (UE) and 423 healthy control subjects. The PCR products were directly sequenced. Multivariate logistic regression was performed to analyze the relationship between gene polymorphism of NPY promoter and cerebral stroke subtypes according to TOAST by removing the confounding variables. Results Significant differences in the frequency of genotype CC and allele C at position of-399T/C were noted between the patients with SAO and controls (P=0.046, P=0.010). Compared with the control group, patients with LAA and SAO were more likely having high level of uric acid, hypertension, diabetes mellitus and heard disease (P＜0.05). No statistic differences in the frequency of genotype DD and allele D at position of-883Tgins/del were noted between patients with SAO and controls (P=0.0605, P=0.155). Gene polymorphisms of-399T/C,-883Tgins/del and -602G/T did not associate with an increased risk of having LAA, CE, ODE and UE.Conclusions The gene polymorphisms of promoter in position of-399T/C gene maybe associate with the happening of SAO; allele C at the position of-399T/C may raise the risk of the disease. There is no relationship between the gene polymorphisms of promoter at position of-399T/C, -883Tgins/del, -602G/T and the patients with LAA, CE, ODE and UE. High level of uric acid, hypertension, diabetes mellitus and heard disease history are the risk factors of LAA and SAO.
