Prognostic factors of carcinomatous meningitis: an analysis of 63 cases
10.3760/cma.j.issn.1671-8925.2010.09.016
- VernacularTitle:63例脑膜转移瘤预后因素分析
- Author:
Shuai YI
1
;
Qing-Song PANG
;
Lu-Jun ZHAO
;
Zhi-Yong YUAN
;
Ling CAO
;
Ping WANG
Author Information
1. 天津医科大学附属肿瘤医院
- Keywords:
Meningeal neoplasms;
Drug therapy;
Radiotherapy;
Prognosis;
Risk factor
- From:
Chinese Journal of Neuromedicine
2010;09(9):927-931
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis factors of carcinomatous meningitis (CM).Methods The medical records of 63 patients with CM treated in our hospital from 1998 to 2008 were retrospectively analyzed. The chief prognosis factors evaluated were gender, age, primary tumor type,Karnofsky performance status (KPS) scores, interval between diagnosis of primary tumor and CM,treatment, radiation dose and primary tumor control status. Kaplan-Meier method was employed to calculate the survival time and plot the survival curves. Log-rank test was used to evaluate the differences between the groups. Cox regressive model was used to analyze the prognostic factors. Results All patients died by the end of follow-up. The survival time ranged from 2 to 732 d and the overall one-year survival rate was 7.9% with a median survival time of 67 d. In multivariate analysis, KPS scores, primary tumor control status, interval between diagnosis of primary tumor and CM were independent prognostic factors. Conclusions The main prognostic factors of CM are KPS scores, primary tumor control status, and interval between diagnosis of primary tumor and CM. The most effective treatment modalities still need to be confirmed and individual treatment for each patient with CM should be recommended in clinic.
