Correlation between changes of serum S100B protein level and cognition disorders in patients with brain concussion
10.3760/cma.j.issn.1671-8925.2010.08.024
- VernacularTitle:脑震荡患者血清S100B蛋白的变化与认知功能障碍的相关性
- Author:
Yu LIN
1
;
Chuan-Ping HUANG
;
Jian LIU
;
Yun-Fei CAO
;
Pei-Zeng XIE
;
Xian-Bing WANG
Author Information
1. 解放军第421医院
- Keywords:
Brain concussion;
S100B;
Cognition disorders;
Mini-mental state examination
- From:
Chinese Journal of Neuromedicine
2010;09(8):844-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the changes of serum S100B protein level in acute phase and the scores of mini-mental state examination (MMSE) in patients with brain concussion, and evaluate the role of serum S100B protein level in the prognosis of cognition disorders after brain concussion. Methods The serum S100B protein level was determined by an enzyme linked immunosorbent assay (ELISA) in 126 cases of brain concussion 6 and 12 h, and 3 d after admission, and these data were compared with those in 96 cases of moderate head trauma without transitory loss of consciousness (admitted to our hospital at the same period, control group). MMSE was performed 1 and 14 d and 3 months after injury, and the correlation between the changes of serum S100B level in acute phase and MMSE scores was observed. Results As compared with that in control group,the serum S100B protein level in patients with brain concussion was significant higher at 6 and 12 h after admission(P＜0.05). The serum S100B protein level at 6 h, but not at 12 h and 3 d after admission, was closely associated with the MMSE scores 1 and 14 d and 3 months after injury. Conclusion Early elevation of S100B within 6 h of admission in patients with brain concussion, obviously correlating with cognitive impairment, may serve as an important prognostic marker in predicting clinical outcome of cognition disorders after brain injury.
