Dynamic changes of the levels of inflammation factors after carotid artery stenting and their relation to restenosis in patients with transient ischemic attack
10.3760/cma.j.issn.1671-8925.2010.07.003
- VernacularTitle:短暂性脑缺血发作患者介入治疗术后炎性因子的动态变化及其与再狭窄的关系
- Author:
Zhang-Yong XIA
1
;
Hua YANG
;
Huai-Qian QU
;
Ke-Mi CUI
;
Wei-Dong CHENG
Author Information
1. 山东省聊城市人民医院
- Keywords:
Carotid stenosis;
Transient ischemic attack;
Carotid stenting;
Interleukin-6;
Tumor necrosis factor α;
C-reactive protein
- From:
Chinese Journal of Neuromedicine
2010;09(7):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of the levels of Interleukin-6 (IL-6), tumor necrosis factor a (TNF-α) and c-reactive protein (CRP) after carotid artery stenting (CAS) and their relation to restenosis in patients with transient ischemic attack. Methods The patients were divided into group A (with 1 stenting and 1 lesion, n=38) and group B (with 2 stenting and 2 lesions, n=29) according to the pathologic changes and complicated degrees of CAS, and all the patients were divided into restenosis group (n=14) and non-restenosis group (n=48) according to the examination results of cervical CTA 1 y after CAS. The levels of EL-6, TNF-α and CRP were measured before CAS and 1 h, 2 w, 1 and 6 mon, and 1 y after stents. The level of CRP was measured by enhanced immunoturbidirnetic assay, and the levels of IL-6 and TNF-a were measured by radioimmunoassay. Results to the follow-up survey, 1 died and 4 were lost. Fourteen had restenosis of different degrees. The restenosis rate more than 50 percent was noted in 3 patients. Compared to those before CAS, the levels of CRP, IL-6 and TNF-α were increased rapidly after CAS (P<0.05). Compared to those in the group A, the levels of CRP, IL-6 and TNF-α in the group B 1 h, 2 w and 6 mon after CAS were obviously increased (P<0.05). Compared to those in the non-restenosis group, the levels of CRP, IL-6 and TNF-α in the restenosis group 1 h, 2 w and 6 mon after CAS were obviously increased (P<0.05). Conclusion The levels of IL-6, TNF-α and CRP increased rapidly after CAS, then reduced gradually and increased once again 6 months after CAS, which was notable in restenosis group. They can be the reference indexes of the forecast for early restenosis.
