Effects of naloxone on immunoregulation in patients with traumatic brain injury
10.3760/cma.j.issn.1671-8925.2010.06.025
- VernacularTitle:纳络酮对颅脑损伤患者免疫调节的影响
- Author:
Xu CHEN
1
;
Cheng-Hui LIU
;
Guo-Liang GUAN
;
Qi-Ming LIN
;
Shi-Xing LIANG
Author Information
1. 南方医科大学附属南海人民医院
- Keywords:
Craniocerebral injury;
Monitoring,immunologic;
Naloxone;
Pharmacotherapy
- From:
Chinese Journal of Neuromedicine
2010;9(6):641-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To dynamically monitor the humoral immune parameters in the blood and cerebrospinal fluid and analyze the relationship between immunity and disease development and recovery after brain injury to explore the clinical effect of naloxone combined with mild hypothermia on the treatment of brain injury.Methods One hundred patients with severe craniocerebral injury admitted to our hospital from January 2008 to December 2008,were prospectively studied and equally divided into treatment group and control group.The control group was given conventional therapy,while the treatment group was given naloxone combined with mild hypothermia besides conventional therapy.We detected the changes of the contents of IgG,IgA,IgM,complement c3 and albumin in the blood and cerebrospinal fluid on the 4th,14th,and 21st d of injury.Then we compared the differences between the humoral immune parameters and both the clinical infection rates and the disability grades in the 2 groups.Results No statistical significance in the immune indexes of blood and the IgM content of cerebrospinal fluid was found between the control group and the treatment group (P>0.05),while statistical significances in the changes of the contents of IgG,IgA,IgM and albumin in the cerebrospinal fluid,the clinical infection rates and the disability grades were found between the 2 groups (P<0.05).The positive rate of complement c3 in the cerebrospinal fluid was statistically significant between the 2 groups on the 4th d of injury (P<0.05).Conclusion Naloxone combined with mild hypothermia has definite curative effect and no obvious adverse reaction in treating patients with craniocerebral injury,may resulting from the humoral regulation of naloxone.
