Effect of small doses of thrombin inhibitor:Shuxuetong injection on hematoma volume and low-density areas in acute stage of cerebral hemorrhage
10.3760/cma.j.issn.1671-8925.2010.03.024
- VernacularTitle:小剂量凝血酶抑制剂-疏血通注射液对脑出血急性期血肿体积及周围缺血影响
- Author:
Xiao-Fei QI
1
;
Ze-Yu LI
;
Juan HE
Author Information
1. 内蒙古医学院附属医院
- Keywords:
Cerebral hemorrhage;
Acute stage;
Small doses of thrombin inhibitor
- From:
Chinese Journal of Neuromedicine
2010;9(3):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of small doses of thrombin inhibitor(Shuxuetong injection)on the absorption of hematoma and the volume of low-density areas in acute stage of cerebral hemorrhage.Methods One hundred and twenty patients with acute cerebral hemorrhage,admitted to our hospital from February 2004 to April 2009,were randomly divided into treatment and control groups (n=60).The treatment group was treated with routine western medicine combined with thrombin inhibitor (Shuxuetong injection)4 mL dairy intravenously for 15 consecutive d.CT scan was employed to evaluate the hematomas volume and changes of low-density areas 7 and 21 d after the treatment.Results The volume of hematomas in the treatment group(17.8±2.1 mL,8.2±2.1 mL)reduced significantly as compared with that in the control group(21.3±1.6 mL,15.1±1.2 mL)on the 7~(th) and 21~(st) d(P<0.05).The volume of low-density area in the treatment group(1.433 mm)was significantly reduced as compared with that in the control group(3.041 mm,P<0.05).Conclusion Small doses of thrombin inhibitor (Shuxuetong injection)can promote the absorption of hematoma,reduce the volume of low-density areas surrounding hematomas in acute stage of cerebral hemorrhage.
