Relationship between levels of serum IL-1β and IL-1Ra and restenosis in patients with intra and extra-cranial arteriostenosis after stent-assisted angioplasty
10.3760/cma.j.issn.1671-8925.2010.03.015
- VernacularTitle:颅内外动脉狭窄支架成形术后血清IL-1β、IL-1Ra的变化及与再狭窄的关系
- Author:
Jian HAN
1
;
Fu-Qiang GUO
;
Tian ZHANG
;
Jian-Hong WANG
;
Wen-Bin WU
;
Neng-Wei YU
Author Information
1. 四川省人民医院
- Keywords:
Interleukin-1 receptor antagonist restenosis;
Receptor antagonist;
Restenosis
- From:
Chinese Journal of Neuromedicine
2010;9(3):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the levels of serum interleukin-1β(1L-1β)and interleukin-1 receptor antagonist(IL-1Ra),the IL-1Ra/IL-1β ratio and the relationship between the levels of thern and the restenosis in patients with intra-and extra-cranial arteriostenosis after stent-assisted angioplasty.Methods Thirty-one patients with cerebral artery stenosis,admitted to our hospital from April 2003 to March 2006,were treated with stent-assistant angioplasty and followed up for 6-12 months.The relationship was analyzed between the restenosis of cerebral artery and both the levels of serum IL-1β,IL-1Ra and the IL-1 Ra/IL-1β ratio before and 1 h,1,3 and 5 d after stent-assisted angioplasty.Results The condition of 31 stents in 31 blood vessels of cerebral arteries was observed and followed up 6 to 12 months after the operation.Restenosis was noted in 6(19.3%)with 3 restenosis superior to 50% and 3 restenosis from 10%-30%.No obvious difference of the levels of serum IL-1β and IL-1Ra,the IL-1Ra/IL-1β ratio between restenosis group and non-restenosis group before the operation was found (P>0.05);IL-11β and IL-1Ra levels were positively correlated before the operation.The levels of serum IL-1β and IL-1Ra 1h,1,3 and 5 d after the operation were superior to those before the operation,respectively(P<0.05).The levels of serum IL-1β and IL-1Ra in the restenosis group showed no significant difference to those in the non-restenosis group 6 to 12 months alter the operation(P>0.05);however,the IL-1Ra/IL-1β ratio in the restenosis group was significantly lower than that in the non-restenosis group (P<0.05);positive correlation between the levels of IL-1β and IL-1Ra was observed.Conclusion The levels of serum IL-1β and IL-1Ra were associated with the inflammatory process after the operation and the immune maladjustment of IL-1β and IL-1Ra might be correlative to the restenosis,indicating that the IL-1Ra/IL-1β ratio might be an available index for monitoring the restenosis.
