Accuracy of MSCT perfusion imaging in grading the astrocytic tumors
10.3760/cma.j.issn.1671-8925.2010.03.012
- VernacularTitle:多层螺旋CT灌注成像对星形细胞肿瘤分级的准确性评价
- Author:
Yi WANG
1
;
Wei-Guo ZHANG
;
Shu-Nan WANG
;
Hua-Liang XIAO
;
Jin-Hua CHEN
;
Le-Tian ZHANG
;
Qi-Sheng RAN
Author Information
1. 第三军医大学第三附属医院野战外科研究所
- Keywords:
Multi-slice spiral CT perfusion imaging;
Gliomas;
Astrocytic tumors
- From:
Chinese Journal of Neuromedicine
2010;9(3):266-269,272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the sensitivity and specificity of CT perfusion(CTP)parameters in grading the astrocytic tumors.Methods Fifty-three patients with brain tumors underwent CTP examination,and the astrocytie tumors confirmed by operation and pathology(n=30)were selected and divided into high-grade group(n=19)and low-grade group(n=11).Perfusion scanning on the brain was performed by 64-slice spiral CT angiography and the data were analyzed by AW 4.2P software.Cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and permeability surface(PS)on the maximum perfusion area and the normal brain tissues in the opposite side were measured.Results High-grade group showed significantly higher CBF,CBV and PS values as compared with the low-grade group(P<0.05).However,the MTT values was not significantly different between the 2 groups(P>0.05).The under-ROC curve areas of the CBF,CBV and PS values between these 2 groups were 0.914,0.876 and 0.914,respectively;while that of MTT was only 0.455 and could not help differentiating the diagnosis.When the optimal limit values of these indicators for differentiation specificity was 81.8%,81.8% and 91.9%,respectively.Conclusion The CBF,CBV and PS values of multi-slice CTP show high sensitivity and specificity in differentiating the diagnosis of high-and low-grade astroeytic tumors.