Expression of trkA and role of PG490 on its expression in experimental autoimmune encephalomyelitis models
10.3760/cma.j.issn.1671-8925.2010.03.008
- VernacularTitle:神经生长因子受体trkA在EAE模型中的表达及PG490的作用
- Author:
Fu-Hua XIE
1
;
Cong GAO
;
Xu-Ming XIONG
;
Wei-Jiang LIU
;
Jian-Rui YIN
Author Information
1. 广州医学院附属第二医院
- Keywords:
Neurotrophic factor receptor;
Experimental allergic encephalomyelitis;
PG490
- From:
Chinese Journal of Neuromedicine
2010;9(3):250-252,257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the changes of NGF receptor trkA content and investigate the role and the pathway of PG490 on trkA expression in experimental autoimmune encephalomyelitis (EAE)models.Methods Fourty-eight rabbit models were induced and randomized into model group,PG490 intervention group 1(giving PG490 at the onset)and PG490 intervention group 2(giving PG490 at the recurrence).The clinical scores and pathological changes were observed and the expression changes of trkA in the brain tissue were tested by ELISA methods before and after the treatment with PG490.Results The recurrence in the model group was an extremely slow process.The mean clinical scores in the PG490 intervention groups were significantly lower as compared with those in the model group(P<0.05).No obvious differences of the trkA content were found between the model group and the PG490 intervention group 1(P>0.05);however,significant differences of the trkA content were noted between the model group and the PG490 intervention group 2(P<0.05).Conclusion PG490 can improve the clinical symptoms in EAE models by adjusting the trkA content.
