Clinical observation on mouse nerve growth factor in the prevention of dysfunction of cerebral trauma

VernacularTitle:鼠神经生长因子预防颅脑损伤后功能障碍临床观察
Author: Wei-Ping LIU ¹ ; Xi-Cai YI ; Hai-Ning ZHEN ; Li-Zhou WEI ; Yang LIU ; Zhou FEI
Author Information

1. 第四军医大学西京医院
Keywords: Nerve growth factor; Cerebral trauma; Dysfunction
From: Chinese Journal of Neuromedicine 2010;9(2):193-195
CountryChina
Language:Chinese
Abstract: Objective To assess the clinical effects of mouse nerve growth factor (NGF) on prevention of cerebral trauma-induced dysfunction. Methods Thirty-three patients with cerebral trauma, admitted to our hospital from Mar. 2007 to Feb. 2009, were chosen as NGF-treated group and NGF were injected intramuscularly at a daily dose of 40 μg. Control group was composed of another 33 patients, whose consciousness and traumatic condition were comparable with those of NGF-treated group and conventional treatment was given. The data of Glasgow coma scale (GCS) and Karnofsky performance status (KPS) were analyzed in the 2 groups. Results The NGF-treated group showed significantly high CCS 14 d after treatment as compared with the control group (P<0.05). The KPS in the NGF-treated group was statistically higher than that in the control group 6 months after the treatment was ended (P<0.05). Conclusion NGF, one of the most important neurotrophin, is safe and effective in the prevention of postinjury dysfunction.