Clinical observation on nerve growth factor in the treatment of severe craniocerebral trauma
10.3760/cma.j.issn.1671-8925.2010.02.020
- VernacularTitle:神经生长因子治疗重型颅脑损伤的临床观察
- Author:
Fang-Fang WU
1
;
Sheng-Hua CHU
;
Yan-Bin MA
;
Jian-Hua QIU
;
Hong ZHANG
;
Zhi-An ZHU
;
Ya-Zhuo ZHANG
Author Information
1. 上海交通大学医学院附属第三人民医院
- Keywords:
Nerve growth factor;
Craniocerebral trauma;
Coma
- From:
Chinese Journal of Neuromedicine
2010;9(2):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of nerve growth factor (NGF) on the level of plasma creatine kinase BB (CK-BB) and its clinical effect in patients with severe craniocerebral trauma. Methods Eighty patients with severe craniocerebral trauma (GCS≤8) were randomly assigned to NGF-treated (n=40) and control (n=40) groups. Conventional therapy was performed on these patients and NGF was added into the NGF-treated group. The level of plasma CK-BB in these patients was measured; the clinical prognosis of the patients was evaluated based on the GOS scores 6 months after severe craniocerebral trauma; the condition of regained consciousness was compared between the 2 groups. Results Plasma CK-BB in the NGF-treated group was significantly lower than that in the control group (P<0.05); the recovery rate in the NGF-treated group (24/40) was significantly higher than that in the control group (11/40); the consciousness regained within i month was found in 32 patients in the NGF-treated group but only 18 of that was noted in the control group (P<0.05); NGF-treated group (12.43±6.25) showed a significantly shorter time that consciousness was regained as compared with the control group (15.96±7.58). Conclusion NGF can decrease the level of plasma CK-BB, shorten coma time and improve life quality in patients with severe craniocerebral trauma. Application ofNGF, a safe and effective treatment method, provides a new potential therapeutic strategy for patients with CNS injury.
