Executive dysfunction in patients with hepatolenticular degeneration
10.3760/cma.j.issn.1671-8925.2009.12.019
- VernacularTitle:肝豆状核变性患者的执行功能障碍
- Author:
Gong-Qiang WANG
1
;
Yong-Zhu HAN
;
Ren-Min YANG
;
Xun WANG
;
Kai LI
;
Ji-Yuan HU
;
Qing-Qing LI
Author Information
1. 安徽中医学院神经病学研究所附属医院
- Keywords:
Hepatolenticular degeneration;
Neuropsychology;
Executive function
- From:
Chinese Journal of Neuromedicine
2009;8(12):1262-1264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the characteristics of executive dysfunction in patients with hepatolenticular degeneration (HLD) through neuropsychological tests and explore its mechanism. Methods One hundred and two patients with HLD were chosen and divided into CT/MRI positive (n=70) and CT/MRI negative (n=32) groups in accordance with cerebral imaging and the other 30 healthy subjects were selected as normal control group. These three groups were recorded the results of such imaging data as Raven's standard progressive matrices (R'SPM) test, Stroop color-word test (CWT), trail making test (TMT). Results Imaging data indicated a statistical change of frontal-striatal loops in patients with HLD. Significant differences of the total scores, perception discrimination, serial relationship and abstract reasoning of R'SPM test were showed in the three groups and the word interference time of CWT, B items time-consuming and interference effects of TMT in these groups were statistically different (P<0.05). Conclusion Executive dysfunction appears commonly in patients with HLD. The CT/MRI positive group showed a more serious degree and area of the damage as compared to that in the CT/MRI negative group. Damages of frontal-striatal loops may be one of the important mechanisms of executive dysfunction in patients with HLD.
