Detection of cerebral blood flow with single emission computed tomography in depressive patients
10.3760/cma.j.issn.1671-8925.2009.12.013
- VernacularTitle:抑郁症患者局部脑血流灌注变化研究
- Author:
Jun-Li YU
1
;
Ju JIAO
;
Jie-Hua XU
;
Mu-Hua CHENG
;
Feng ZHANG
;
Yong ZHANG
Author Information
1. 中山大学附属第三医院
- Keywords:
Depression;
Regional cerebral blood flow;
Radionuclide imaging
- From:
Chinese Journal of Neuromedicine
2009;8(12):1241-1243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of regional cerebral blood flow (rCBF) with SPECT in depressive patients, and explore the diagnosis value of rCBF imaging for depression. Methods The rCBF imaging was detected by single emission computed tomography (SPECT) on 32 depressive patients and 10 normal subjects, and the characteristics of rCBF changes were assessed with a region-of-interest (ROI) technique. Normal MRI scans were conducted on 11 patients at the same stage. Results Abnormal rCBF was showed in 31 patients with 71 focuses that were located in the bilateral frontal lobe (9), the basal ganglia (5) and the limbic system (57), including the temporal lobe, the hippocampus, the cingulated gyms and the left insular cortex. All abnormalities presented a decreased rCBF except the basal ganglia. No differences in the incidences of abnormal rCBF were found on bilateral hemisphere (χ~2=2A09,P=0.790). Only 3 MRI-detected patients (2 with gently encephalanalosis, 1 with hippocampus atrophies) were found abnormality, while abnormal rCBF was observed in all these 11 patients. Conclusion Most depressive patients show a decreased rCBF at the cerebral limbic system, but part of them exist an increased rCBF at the basal ganglia. The changes of rCBF in depressive patients are sensitively observed by SPECT, suggesting its diagnosis values on depression.
