Expression and significance of Stathmin in human glioma vascular endothelial cells
10.3760/cma.j.issn.1671-8925.2009.12.006
- VernacularTitle:Stathmin在脑胶质瘤血管内皮细胞中的表达及意义
- Author:
Xiao-Dong LIU
1
;
Lu-Yan MU
;
Xiao-Qian LIU
Author Information
1. 吉林省通化市人民医院
- Keywords:
Stathmin;
CD105;
Vascular endothelial cells;
Glioma
- From:
Chinese Journal of Neuromedicine
2009;8(12):1213-1216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of stathmin and CD105 in human glioma vascular endothelial cells and explore their significant roles in glioma angiogenesis. Methods The protein expressions of stathmin and CD 105 in the vascular endothelial cells was examined by SP immunohistochemical staining in 10 normal cerebral tissue samples and 78 cases of glioma. The microvessel density (MVD) was measured to analyze the tumor angiogenesis. Results No expression of statnmin and CD105 was found in the normal human brain tissue; while high expression level of both stathmin and CD 105 was showed in the vascular endothelial cells of glioma. The expression level of stathmin and CD 105 and the value of MVD increased following the rise of the pathological grades of glioma; significant linear correlation was showed between the values of stathmin-MVD and CD105-MVD and the pathological grades of the glioma (r=0.912, P<0.05; r=0.936, P<0.05); stathmin-MVD and CD 105-MVD were also positively correlative (r=0.996, P<0.05). Conclusion The Stathmin and CD 105 is highly expressed in the vascular endothelial cells of human glioma, suggesting its important role in the tumor angiogenesis.
