Pituitary stalk interruption syndrome due to trauma: analysis of 2 cases
10.3760/cma.j.issn.1671-8925.2009.08.024
- VernacularTitle:二例外伤性垂体柄中断综合征的临床探讨
- Author:
Zhuo-Na YIN
1
;
Wen-Sheng JIN
;
Wei-Guo XU
;
Ai-Min DENG
;
Song ZHANG
;
Tian-Dong LI
;
Li-Xin HAN
Author Information
1. 广州军区广州总医院
- Keywords:
Brain trauma;
Pituitary stalk interruption syndrome;
Anterior pituitary lobe hypofunction
- From:
Chinese Journal of Neuromedicine
2009;8(8):848-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome (PSIS) for its better understanding. Methods The clinical manifestations and endocrine alterations were analyzed retrospectively in 2 PSIS cases, and the literatures concerning this disease were reviewed. Results Both of the 2 adult patients had definite history of head injuries, and one of them exhibited nervous system sequelae. The diagnoses remained erroneous for 15 and 2 years, respectively. This disease was characterized by gradual clinical hypopituitarism, and both of the 2 patients were admitted for pituitary crisis, which occurred for several times in 1 case;neither of the patients had diabetes insipidus. Endocrine examination suggested hypofunction of the thyroid gland, sexual gland and adrenal glands due to hypopituitarism. Magnetic resonance imaging revealed pituitary atrophy, pituitary stalk interruption and posterior lobe hyperintensity in the infundibular recess. So far only 2 juvenile cases of traumatic PSIS were reported, which had distinct differences from early-onset PSlS and from simple traumatic hypopituitarism without pituitary stalk interruption. Conclusion Traumatic PSIS is a rare clinical entity. In cases of endocrine alterations following head injury, traumatic PSIS might be suspected and appropriate treatment should be administered.
