Analysis of the factors affecting the clinical outcomes of corpus callosal gliomas
10.3760/cma.j.issn.1671-8925.2009.08.017
- VernacularTitle:胼胝体胶质瘤的预后影响因素(附60例分析)
- Author:
Chun-Lin WANG
1
;
Yi-Cheng LU
;
Ju-Xiang CHEN
;
Tao XU
;
Zhen-Yu ZHAO
;
Yuan PAN
;
Guo-Han HU
;
Chun LUO
;
Yong YAN
;
Tao WANG
Author Information
1. 第二军医大学附属长征医院
- Keywords:
Corpus callosum;
Gliomas;
Prognosis;
Risk factors
- From:
Chinese Journal of Neuromedicine
2009;8(8):820-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the factors that influence the prognosis and particularly the survival of patients with corpus callosal gliomas. Methods A retrospective analysis of the clinical data was conducted involving 60 patients with corpus callosal gliomas treated between January, 1995 and December, 2007. All the patients underwent surgical tumor resection with postoperative radiotherapy and chemotherapy. Kaplan-Meier and Cox regression model were used to evaluate the possible prognostic factors including the patients' gender, age, preoperative Karnofsky performance status (KPS), tumor locations, preoperative epilepsy, histological grade, enhancement pattern on magnetic resonance imaging (MRI), extent of surgical resection, and tumor size. Results Kaplan-Meier analysis revealed that age, preoperative KPS score, and histological grade had significant influences on progression-free survival (PFS) and overall survival time of the patients. The tumor location had a significant impact on the overall survival time of the patients, but did not obviously affect the PFS. Multivariate analysis with the Cox regression model indicated that age, histological grade, and extent of surgical tumor resection significantly influenced the overall survival time of the patients, and age and histological grade of the tumor significantly affected the PFS. Conclusion A younger age, lower pathological grade and radical surgical resection of the tumor are the protective prognostic factors in patients with corpus callosal gliomas, while gender, tumor size, tumor location, and KPS score before operation have no prognostic significance.
