Expression and correlation of vascular endothelial growth factor and Ki-67 antigen in human brain astrocytoma

VernacularTitle:血管内皮生长因子和Ki-67在人脑星形细胞瘤中的表达及相关性
Author: Zhi-Dong LIAO ¹ ; Shou-Cheng XIE ; Ya-Ling KUANG
Author Information

1. 广东省梅州市人民医院
Keywords: Astroeytoma; Vascular endothelial growth factor; Ki-67
From: Chinese Journal of Neuromedicine 2009;8(8):817-819
CountryChina
Language:Chinese
Abstract: Objective To study the expressions of vascular endothelial growth factor (VEGF) and Ki-67 antigen and their correlation in human brain astrocytorna. Methods Immunohistochemistry with SP method was employed to detect the expressions of VEGF and Ki-67 in 60 human brain astrocytoma tissue (grade Ⅰ-Ⅱ 28 cases, grade Ⅲ 20 cases, grade Ⅳ 12 cases) and 30 normal tissues adjacent to the tumors. Results VEGF and Ki-67 were not expressed in the normal brain tissues adjacent to the astrocytoma, but their expressions were detected in all the astroeytoma tissues of different grades (P<0.05). High-grade astrocytomas showed significantly higher VEGF and Ki-67 expression than low-grade astrocytomas (P<0.05), and a positive correlation was noted between VEGF and Ki-67 expressions (r=0.310, P<0.05). Conclusion VEGF and Ki-67 expressions can provide important evidence for evaluating the malignancy and clinicopathologieal grading of human astrocytoma.