Aquaporin 4 and vascular endothelial growth factor participate in the formation of peritumoral edema of gliomas and brain metastases
10.3760/cma.j.issn.1671-8925.2009.08.015
- VernacularTitle:血管内皮生长因子与水孔蛋白4在胶质瘤及脑转移瘤中的表达及意义
- Author:
Qi-Jia TAN
1
;
Li-Sheng HE
;
Zhi-Xiong LIN
;
Fu HAN
;
Tao HUANG
;
Ze-Sun ZHANG
Author Information
1. 广东省中医院
- Keywords:
Gliomas;
Brain metastatic tumors;
Vascularendothelial growth factor;
Aquaporin 4
- From:
Chinese Journal of Neuromedicine
2009;8(8):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and aquaporin 4 (AQP4) in giiomas and brain metastases, and explore the role of VEGF and AQP4 in the histopathology and formation of peritumoral edema of primary and metastatic gliomas. Methods Immunohistocbemical method was used to examine the protein expression of VEGF and AQP4 in 73 paraffin-embeded, pathologically confirmed glioma and 15 metastatic tumor specimens collected between 1999 and 2001. Eight normal brain tissue specimens were used as the control. Results VEGF protein was not detected in normal brain tissues. VEGF expression was detected in gliomas and the expression level increased obviously along with the histological grade of the tumor. Significant differences were found in VEGF expression between malignant and low-grade gliomas, between low-grade gliomas and normal brain tissues, and between intracranial metastatic tumors and normal brain tissues and low-grade gliomas (P<0.05), but not between intracranial metastatic tumors and malignant gliomas (P>0.05). AQP4 protein expression was found in all the collected samples, and its expression differed significantly between normal brain tissues and malignant gliomas or intracranial metastatic tumors, and also between low-grade gliomas and malignant gliomas or intracranial metastatic tumors (P<0.05), but not between normal brain tissues and low-grade gliomas or between intracranialmetastatic tumors and malignant gliomas (P>0.05). VEGF protein expression showed a significant positive correlation to AQP4 protein expression (r=0.516, P<0.05). Conclusion As important molecular biological factors, VEGF and AQP4 participate in the formation peritumoral brain edema of gliomas and exhibit a synergie effect in this process.
