Balloon 32P internal radiotherapy with concurrem local chemotherapy for brain glioma: a clinical evaluation
10.3760/cma.j.issn.1671-8925.2009.07.014
- VernacularTitle:球囊法32P内放疗同步内化疗综合治疗脑胶质瘤的临床研究
- Author:
Ting-Gang FU
1
;
Yan-Zhi WANG
;
Shou-Chang XIANG
;
Jie SONG
;
Peng XU
Author Information
1. 山东省临沂市沂水中心医院
- Keywords:
Balloon method;
Internal radiotherapy;
Internal chemotherapy;
Glioma
- From:
Chinese Journal of Neuromedicine
2009;8(7):700-703
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of balloon 32P internal radiotherapy with concurrent local chemotherapy in the treatment of brain glioma. Methods A total of 228 patients with brain gliomas were enrolled in this study. Of these patients, 64 received conventional radiotherapy (group A), 93 received balloon 32P internal radiotherapy (group B), and 71 had internal radiotherapy with concurrent local chemotherapy (group C). The response rates, average survival period, and the 1, 3, and 5-year survival rates were compared between the 3 groups to evaluate the clinical efficacy of the treatments. The Kamofsky's Performance Scores (KPS) after the treatments were also compared to assess the adverse effects associated with the treatments Results Significant differences were found in the response rates, average survival period and 1, 3, and 5-year survival rates between the 3 groups. The KPS scores after the treatment differed significantly between groups B and A and between C and A, but not between B and C. Conclusion Balloon 32P internal radiotherapy produces significantly better effect than conventional radiotherapy, and concurrent local chemotherapy even further enhances the effect of balloon 32P internal radiotherapy. Conventional radiotherapy results in greater adverse effects than the other two procedures, which produce comparable adverse effects.
