Effect of urapidil in reducing brain temperature in hot and humid environment

VernacularTitle:乌拉地尔降低脑温的实验研究
Author: Qing ZHOU ¹ ; Shi-Zhong ZHANG ; Ping PENG ; Ce LIU ; Gang WU ; Yong-Ge XU ; Jing-An ZHOU
Author Information

1. 解放军总医院附属第二医院
Keywords: High temperature and humidity; Brain temperature; Urapidil
From: Chinese Journal of Neuromedicine 2009;8(6):618-620
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect ofurapidil in lowering the brain temperature in hot and humid environment. Methods Ninety soldiers stationed in Chinese Nansha Islands were divided into veteran group, untreated new recruit group and new recruit group with urapidil (tablet) treatment. All the soldiers were asked to complete a running exercise for 3000 m within 20 min in hot and humid environment, and their body temperature before and after the exercise was measured to evaluate the brain temperature changes. Results Before the running exercise, no significant differences was found in the body temperature among the 3 groups. The body temperature of the soldiers showed significant differences after the exercise, and the untreated new recruit had the most obvious elevation of the body temperature, whereas those with urapidil treatment showed the least elevation. Conclusion Veterans and new recruit show different tolerance and adaptability to hot and humid environment, and urapidil tablets can help reduce brain temperature increment induced by hot and humid environment.