Correlation of plasma van Wilebrand factor changes after stenting to the degree of preoperative intracranial major artery stenosis in patients with acute atherosclerotic cerebral infarction
10.3760/cma.j.issn.1671-8925.2009.06.009
- VernacularTitle:脑梗死患者颅内大动脉支架置入术前后vWF水平变化与血管狭窄程度的关系研究
- Author:
Jing-Jing SI
1
;
Ya-Jie LIU
;
Zhen-Hua LIU
Author Information
1. 南方医科大学珠江医院
- Keywords:
Atherosclerotic cerebral infarction;
Stenosis;
yon Willebrand factor,Stenting
- From:
Chinese Journal of Neuromedicine
2009;8(6):574-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the correlation between plasma von Wilebrand factor (vWF) changes after stenting and the degree of preoperative intracranial major artery stenosis in patients with acute atherosclerotie cerebral infarction. Methods This study involved 38 consecutive patients with acute cerebral infarction due to intracranial major artery atherosclerosis, who were admitted between February and October 2008 and underwent stent placement in the stenotic arteries. Thirty healthy volunteers were also recruited to serve as the control group. The patients were divided into severe stenosis group (with stenosis of the intracranial major artery≥70%) and non-severe stenosis groups. Venous blood samples were obtained from the subjects on the morning of the first and 7th days after admission to measure the plasma levels of vWF using sandwich enzyme-linked immunosorbent assay. Results The plasma levels of vWF were significantly higher in patients with acute cerebral infarction than in the control group(P=0.000). Compared with those with non-severe stenosis, the patients with severe stenosis exhibited significantly higher plasma levels of vWF (P=0.015) and greater vWF variation after stent placement (P=0.000). Conclusions In patients with acute atherosclerotic cerebral infarction due to severe intracranial major artery stenosis, the plasma levels of vWF and its postoperative variation are positively correlated to the degree of senosis of the culprit arteries, and severer stenosis is associated with greater postoperative damage of the vascular endothelium.
