Changes of nerve conduction velocity in 60Co-irradiated rabbit sciatic nerve autograft after orthotopic replantation
10.3760/cma.j.issn.1671-8925.2009.06.007
- VernacularTitle:60Coγ射线辐照神经移植后神经传导速度观察
- Author:
Xin-Yuan WANG
1
;
De-Hai CHANG
;
Xu-Jun WEI
;
Shi-Hua XIE
;
Chun-Ming HAN
;
Jin-Sheng SHENG
Author Information
1. 解放军第10医院
- Keywords:
Cobalt-60 irradiation;
Ex vivo nerve;
Orthotopic replantation;
Nerveconduction velocity
- From:
Chinese Journal of Neuromedicine
2009;8(6):567-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of nerve conduction velocity in degenerative rabbit sciatic nerve authograft induced by 60Co irradiation after orthotopic replantation. Methods A 30-mm-long segment was severed from normal adult rabbit sciatic nerve and exposed to 60Co irradiation at the dose of 350 Cry to induce neural degeneration. The nerve segment was then replanted orthotopicaily, and the nerve conduction velocity was determined using electrophysiological test at 4, 6 and 8 months after the replantation. Results At 6, 8 months after the replantation, the nerve conduction velocity in the degenerative nerve autograft showed no significant difference from that in normal sciatic nerve (P>0.05). But at 4 months after the replantation, the nerve conduction velocity in the autograft was significantly lower than the normal velocity (P<0.05). Conclusion The nerve conduction velocity can be obtained by replantation of a long (3 mm) degenerative nerve segment due to 60Co irradiation.
