Association between cutaneous adverse reactions to antiepileptie drugs and HLA-B*IS02 allele
10.3760/cma.j.issn.1671-8925.2009.05.015
- VernacularTitle:抗癫痫药物皮肤不良反应与HLA-B*1502基因关联性研究
- Author:
Mei-Mei GAO
1
;
Yi-Wu SHI
;
Mei-Juan YU
;
Xue-Lian LI
;
Peng WANG
;
Xiao-Rong LIU
;
Bing-Mei LI
;
Yu-Hong DENG
;
Hao-Hui CHANG
;
Wei-Ping LIAO
Author Information
1. 广州医学院附属第二医院
- Keywords:
HLA-B*1502;
Antiepileptie drugs;
Cutaneous adverse drug reactions
- From:
Chinese Journal of Neuromedicine
2009;8(5):493-495,499
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between cutaneous adverse drug reactions (CADRs) caused by antiepileptic drugs and HLA-B*1502 allele. Methods In 31 epileptic patients presented to the Epilepsy Clinic of the Second Affiliated Hospital of Guangzhou Medical College between January 2007 and May 2008, 13 had CADR to carbanazepine (CBZ) including 6 with Stevens-Johnson syndrome (SJS) and 7 with mild maculopapular exanthona (MPE);15 were CBZ-tolerant, and 3 had lamotrigine (LTG)-indueed MPE. All the patients underwent examinations using polymerase chain reaction with sequence specific palmers to analyze HLA -B*1502 allele frequencies, with 30 healthy subjects without a history of using CBZ or LTG as the control. Results HLA-B*IS02 allele frequency was 100% (6/6) in patients with CBZ-SJS, 57% (4/7) in patients with CBZ-induced MPE, and 33% (1/3) in patients with LTG-induced MPE. The frequency was 7% (1/15) in CBZ-tolerant patients and 10% (3/30) in the control subjects. Compared with the CBZ-tolerant patients and the control subjects, the patients with CBZ-induced SJS and MPE had significantly increased HLA -B*1502 allele frequency (P<0.05). Conclusions HLA-B*1502 allele is associated with CADRs to CBZ in epileptic patients.
