Correlation between cerebral white matter lesions in normal appearing region and high-sensitive C-reactive protein in patienm with lacunar infarction
10.3760/cma.j.issn.1671-8925.2009.04.014
- VernacularTitle:腔隙性脑梗死形似正常区的白质损害与超敏C反应蛋白的关系
- Author:
Xiang-Qian ZHANG
1
;
Bing-Xun LU
;
Zhen-Hua LIU
;
Tao-Ping LI
Author Information
1. 南方医科大学南方医院
- Keywords:
Lacunar infarction;
White matter lesion;
Diffusion tensor imaging;
High-sensitive C-reactive protein
- From:
Chinese Journal of Neuromedicine
2009;8(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of the cerebral white matter lesions in the normal appearing region using the diffusion tensor imaging (DTI)and its correlation to high-sensitive C-reactive protein(hs-CRP)in patients with lacunar infarction(LI).Methods Thirty-two patients with LI and 10 healthy control subjects matched for age,educational level,and socioeconomic status were enrolled in this study.T1-weighted imaging(T1WI),T2WI,diffusion-weighted imaging(DWr),FLAIR sequence,and DTI of the head were performed in these subjects,and the fractional anisotropy(FA)and average diffusion coefficient(ADC)values were measured in 25 regions of interest(ROI)in the brain with normal appearances on T1WI and T2WI.The serum levels of hs-CRP were also detected using immunoturbidimetric assay. Results Compared to the control subjects,patients with LI had lowered FA in the whire matter in the bilateral frontal lobes, genu of the corpus callosum, bilateral anterior cingulum,bilateral ccntrum semiovale,bilateral optic radiation,and peripheric white matter ofthe left anterior andposterior angles.Inthe LI patients,the FA of the white matter in the left and right frontal lobes and the genu of the corpus caliosum showed obvious inverse correlations to serum hs-CRP level (r=-0.642,P=0.021;r=-0.388,P=0.016;r=-0.402,P=0.028).The ADC of the LI patients wassignificantly increased in the trunk and~lenium of the corpus callosum,the left centrum semiovale,and the peripheric white matter of the left posterior angle and the left parahippocampal gyrBs(P＜0.05),showing no significant correlations to serum hs-CRP levels. Conclusions In the early stage of LI,white matter damages are present in multiple regions with normal appearance on conventional magnetic resonance images.The close inverse correlation of the FA in the damaged white matter to serum hs-CRP level in LI pailents suggests that arteriosclerosis plays an important role in the pathogenesis of LI.DTI Call be an important diagnostic modality for early detection,prognostic evaluation and therapeutic effect assessment of LI.
