Association of C291T polymorphism in the coding region of thrombinactivatable fibrinolysis inhibitor gene with cerebral infarction

VernacularTitle:TAFI基因编码区C291T的多态性与脑梗死的相关性研究
Author: Fang-Mei HE ¹ ; Yu-Sen CHEN
Author Information

1. 广东医学院附属医院
Keywords: Thrombin activatable fibrinolysis inhibitor gene; Single nucleotide polymorphism; Cerebral infarction
From: Chinese Journal of Neuromedicine 2009;8(3):254-257
CountryChina
Language:Chinese
Abstract: Objective To evaluate the association between C291T polymorphism in the coding region of thrombin activatable fibrinolysis inhibitor (TAFI) and cerebral infarction in Chinese Han population. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine C291T polymorphism in the encoding region of TAFI gene in 173 patients with cerebral infarction and 158 healthy control subjects. Results The frequencies of CC genetype and T alleles carriers ofC291T gene were 53.2% (92/173) and 46.8% (81/173) in the case group and 68.4% (108/158) and 31.6% (50/158) in the control group, respectively. Chi-square test showed significant difference in the frequencies of these genotypes between the two groups (P<0.05). The frequencies of C and T alleles were 70.8% (245/346) and 29.2% (101/346) in the case group, and 81.9% (259/316) and18.1% (57/316) in the control group, respectively, also showing significant differences between the two groups (P<0.05). Conclusion C291T polymorphism in the coding region of TAFI gene is significantly associated with cerebral infarction.