Estimation of oxidative stress in patients with Parkinson's disease

VernacularTitle:帕金森病患者体内氧化压力的定量分析
Author: Wei-Ping GUAN ¹ ; Pei-Gen KUANG ; Sheng-Yuan YU ; Wei-Ping WU ; Hirofumi METOKI
Author Information

1. 解放军总医院
Keywords: Parkinson's disease; Oxidative stress; Low-density lipoprotein
From: Chinese Journal of Neuromedicine 2009;8(1):54-56
CountryChina
Language:Chinese
Abstract: Objective To measure the changes in urinary 8-iso-prostaglandin-F2α (8-iso-PGF2α) and oxidized low-density lipoprotein (ox-LDL) lag time in patients with Parkinson's disease (PD). Methods A case-control study was performed involving 31 male patients with PD (mean age of 59.7 years) diagnosed according to the Calne criteria and 31 age-matched healthy male subjects with comparable status of smoking and life style. For each subject, urinary 8-iso-PGF2α was measured quantitatively using enzyme-linked immunosorbent assay, and LDL oxidizability was measured by determining LDL oxidation lag time in conjugated diene product at 234 nm using Cu-stimulated oxidation. Results Compared to the levels in the control subjects, the PD patients showed significantly increased urinary 8-iso-PGF2α (81.1±1.6 vs 46.9±1.1 ng/mmol creatinine, P<0.05) and significantly reduced LDL oxidation lag time (63.5±6.0 vs 84.4±8.8 min, P<0.05). Conclusion Increased 8-iso-PGF2α and decreased anti-oxidant ability are implicated in the pathogenesis of PD, suggesting the value of appropriate antioxidant therapy in controlling the progression of PD.