Blood pressure regulatory mechanisms and plasma and hypothalamus noradrenaline,epinephrine, angiotensin Ⅱ and renin after acute intracerebral hemorrhage in spontaneously hypertensive rats
10.3760/cma.j.issn.1671-8925.2009.01.008
- VernacularTitle:SHR大鼠脑出血急性期血压调控机制与NE、E、PRA、Ang Ⅱ关系
- Author:
Gao-Cheng LIN
1
;
Gang WU
;
Jun LIN
;
Jun-Xia HOU
;
Qing-Xiao SHI
Author Information
1. 福建医科大学附属第一医院
- Keywords:
Spontaneously hypertensive rats;
Noradrenaline;
Epinephrine;
Rennin;
Angiotensin Ⅱ;
Intracerebral hemorrhage
- From:
Chinese Journal of Neuromedicine
2009;8(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the levels of noradrenaline, epinephrine, angiotensin Ⅱ (Ang Ⅱ) and rennin in acute phase of intracerebral hemorrhage (ICH) and their association with the blood pressure regulatory mechanisms in spontaneously hypertensive rats. Methods ICH was induced in spontaneously hypertensive rats by injection of collagenase into the caudate nucleus. Before and at 1, 3,7 and 14 days after ICH, the plasma and hypothalamus noradrenaline and epinephrine levels were determined with high-performance liquid chromatography, and the Ang Ⅱ levels and renin activity were examined by radioimmtmoassay. Results The plasma noradrenalin and epinephrine levels and hypothalamus noradrenalin level increased significantly after ICH, reaching the peak levels at 24 h (4.31± 0.97 μg/L, 8.55±2.41 μg/L, and 919±128 ng/g; P=0.011, 0.015, and 0.005, respectively) and recovered the preoperative levels till 7-14 days later. The peak levels of plasma rennin and Ang Ⅱ and hypothalamus 035, 0.036, and 0.024, respectively), and were lowered to the preoperative levels 7-14 days after ICH. One day after ICH, the blood pressure of the rats showed a significant increase (P=0.000) followed by obvious reduction on day 3 and recovered the preoperative level 7-14 days after ICH. Conclusion In spontaneously hypertensive rats, the blood pressure regulatory mechanisms following acute ICH can be closely associated with stress-induced activation of the sympathoadrenomedullary system and rennin-angiotensin system.
