Study of survivin protein expression in gliomas and its correlation with malignancy of gliomas

VernacularTitle:脑胶质瘤中survivin蛋白表达情况及其与肿瘤恶化程度关系的研究
Author: Qing-Hai MA ¹ ; Fei WANG ; Wen-Yuan WU
Author Information

1. 内蒙古医学院附属第一医院
Keywords: Glioma; Survivin protein; Gene expression
From: Chinese Journal of Neuromedicine 2009;8(1):16-18
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of survivin in gliomas and its clinical significance. Methods The immunohistochemistry was used to measure protein expression of survivin in 90 cases ofglioma with grade Ⅰ 30cases, gradeⅡ30 cases and gradeⅢ-Ⅳ30 cases. We also used ten normal immunohistochemistry slices resulted from decompression after traumatic brain injury as control group. Results There are survin protein expressions in glioma cytoplasm and the higher the malignancy is, the expression becomes higher. The positive rate of survivin was 16.67% with glioma grade Ⅰ(6/30), 46.67% with gradeⅡ (14/30), and 86.67 % with grade Ⅲ- Ⅳ(26/30) which had statistical significance. However, in normal cerebral tissue, the expression of survivin was negative. Conclusion Survivin expression in gliomas is related to themalignancy of the tumor and it's targeted therapy may become a new management for gliomas.