Effect of exogenous N-methyl-D-aspartate on passive avoidance learning and memory in adult rats
10.3760/cma.j.issn.1671-8925.2009.01.004
- VernacularTitle:外源性N-甲基-D-天冬氨酸对成年大鼠被动回避学习记忆的影响
- Author:
Hao WANG
1
;
Hai-Yang LI
;
Xian-Da YANG
;
Yuan-Li ZHAO
Author Information
1. 首都医科大学附属北京天坛医院
- Keywords:
NMDA receptor;
Passive avoidenee learning and memory;
Neural plasticity
- From:
Chinese Journal of Neuromedicine
2009;8(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of exogenous N-methyl-D-aspartate (NMDA) on passive avoidance learning and memory in adult rats. Methods Slow-release films containing different concentrations of NMDA were prepared and placed on the surface of the rat brain through frontoparietal craniectomy. Three weeks after the operation, the results of step-through test and NMDA receptor activity in the ventromedial prefrontal cortex (vmPFC) and the anterior cingulate cortex (ACC) were compared between the groups. Results No significant differences were found in the latency time (P=0.846) and error frequency (P=0.792) in the step-through test, or in NMDA receptor activity in the vmPFC and ACC (P=0.546) among the groups 3 weeks after the operation. The NMDA receptor activity in these regions, however, tended to decrease with the increment of NMDA concentration in the slow-release films. Conclusion Exogenous NMDA does not produce obvious effect on passive avoidance learning and memory in adult rats. The results of this experiment may provide the basis for further studies of the effects of NMDA in altering the neural plasticity in the impaired brain.
