Relationship between CYP19 gene polymorphism and Alzheimer's disease

VernacularTitle:CYP19基因多态性与阿尔茨海默病遗传易感性的相关性研究
Author: Kai-Feng LI ¹ ; Duo-Bin WU ; Xiao-Ya GAO ; Ya-Jie LIU ; Zhen-Hua LIU
Author Information

1. 南方医科大学珠江医院
Keywords: Alzheimer's disease; CYP19; Gene polymorphism
From: Chinese Journal of Neuromedicine 2009;8(1):2-4
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between CYP19 gene polymorphism and Alzheimer disease. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the allele frequency distribution at the Mfe Ⅰ site of CYP19 gene in 102 patients with Alzheimer disease and 121 healthy control subjects. Results The frequencies of CYP19 ml and m2 alleles showed significant differences between the patient group and the control group (66.2% vs 81.0% and 33.8% vs 19.0%, respectively, X2=12.696, P<0.05). In patients with Alzheimer disease, the frequencies ofm1/m1, m1/m2, m2/m2 genotypes of CYP19 gene were 44.1%, 44.1%, and 11.8%, respectively, showing significant differences from the frequencies in the control subjects (65.3%, 31.4%, and 3.3%, respectively, X2=12.384, P<0.05). Conclusion CYP19 gene polymorphism at the Mfe Ⅰ site is associated with the genetic susceptibility to Alzheimer disease.