Meta-analysis of the relation between the SORLI gene polymorphism and the onset risk of AIzheimer's disease

VernacularTitle:SORL1基因多态与阿尔茨海默病发病风险的Meta分析
Author: Hui-Yan YU ¹ ; Bin QIN ; Hai-Bin ZHOU
Author Information

1. 北京医院
Keywords: Alzheimer's disease; SORL1 gene; Polymorphism; Metβ-analysis
From: Chinese Journal of Neuromedicine 2008;7(12):1287-1290
CountryChina
Language:Chinese
Abstract: Objective To investigate the relation between the rs2070045 locus polymorphism in the SORL1 gene and the onset risk of AD by means of Metβ-analysis. Methods Databases (Medline, Cochrane Library and CBM) were searched using keywords like SORL1, sortilin-related receptor, Alzheimer and so on, and a manual search of citations was also performed from relevant original studies and literatures. All analyses were conducted with Review Manager Version4.2 software. Results 3 literatures with 11 different ethnic groups were studied, totally including the AD group (2927 cases) and the control (3867 cases). The summary OR for studies with frequency of GG+GT genotype at rs2070045 locus in the SORLI gene was 1.19 (95%CI: 1.08-1.31, Z=3.39, P=0.0007), when it compared with the common homozygote ofTT genotype. The summary OR for allele frequency was 1.17 (95%CI: 1.07-1.27, Z=3.67, P=0.0002). Conclusion The metβ-analysis suggests that the polymorphism at rs2070045 locus of SORL1 gene might be a genetic risky factor for AD.