Influence of Tongxinluo capsules on plasma levels of lysophosphatidic acid in patients with acute cerebral infarction
10.3760/cma.j.issn.1671-8925.2008.12.018
- VernacularTitle:通心络胶囊对急性脑梗死患者血浆溶血磷脂酸含量的影响
- Author:
Nan-Hai LIU
1
;
Xiao-Feng HUANG
;
Jian-Lin ZHONG
;
Chun-Qi LIU
;
Fang QIU
Author Information
1. 赣南医学院附属第一医院
- Keywords:
Cerebral infarction,acute;
Lysophospholipids;
Tongxinluo capsules;
Aspirin
- From:
Chinese Journal of Neuromedicine
2008;7(12):1252-1254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma levels of lysophosphatidic acid (LPA) in the patients with acute cerebral infarction and to observe whether the treatment with Tongxinluo capsules would reduce the plasma LPA levels of the patients with acute cerebral infarction. Methods A total of 70 patients were randomly divided into treatment group and control group. Patients in treatment group were treated with normal method, aspirin (100 mg once a day) and Tongxinluo capsules (4 pills for 3 times per day for 60 d). Patients in control group were treated with only normal method and aspirin (100 mg once a day). Plasma LPA levels were measured consecutively in all patients before treatment, 30 d and 60 d after treatment. The effects of Tongxinluo capsules on plasma LPA levels were observed, and the recurrence rate of cerebral infarction was recorded within 2 months. Results The average levels of plasma LPA in the 2 groups were decreased obviously after the treatments (P<0.05), and the changes of plasma LPA levels in treatment group were significant after treatment for 30 d compared with those in control group (P<0.05). The recurrence rate of cerebral infarction in treatment group was lower than that in control group. Conclusions The plasma LPA levels in the patients with acute cerebral infarction can be decreased significantly after treatment with Tongxinluo capsules. Combined treatment of Tongxinluo capsules with aspirin may reduce the plasma LPA levels and the frequency of cerebral infarction events better.
