Safety of a New Synbiotic Starter Formula.
10.5223/pghn.2017.20.3.167
- Author:
Yvan VANDENPLAS
1
;
Antonis ANALITIS
;
Chara TZIOUVARA
;
Athina KOUNTZOGLOU
;
Anastasia DRAKOU
;
Manos TSOUVALAS
;
Antigoni MAVROUDI
;
Ioannis XINIAS
Author Information
1. Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. Yvan.Vandenplas@uzbrussel.be
- Publication Type:Original Article
- Keywords:
Functional gastrointestinal disorder;
Growth;
Infant formula;
Prebiotics;
Probiotics;
Synbiotics
- MeSH:
Bifidobacterium;
Breast Feeding;
Colic;
Constipation;
Crying;
Gastrointestinal Diseases;
Growth Charts;
Humans;
Incidence;
Infant;
Infant Formula;
Lactose;
Milk;
Prebiotics;
Prevalence;
Probiotics;
Reference Values;
Synbiotics*;
World Health Organization
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2017;20(3):167-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. RESULTS: The median age of the infants at inclusion was 0.89 months. Weight evolution was in accordance with the World Health Organization growth charts for exclusive breastfed infants. The evolution of all anthropometric parameters (weight-for-length z score and body mass index-for-age z score) was within the normal range. The incidence of functional constipation (3.2%), daily regurgitation (10.9%), infantile crying and colic (10.5%) were all significantly lower than the reported median prevalence for a similar age according to literature (median value of 7.8% for functional constipation, 26.7% for regurgitation, 17.7% for infantile colic). CONCLUSION: The new synbiotic infant starter formula was safe, resulted in normal growth and was well tolerated. Functional gastro-intestinal manifestations (functional constipation, regurgitation and colic) were significantly lower than reported in literature. Synbiotics (Bifidobacterium lactis and fructo-oligosaccharides) in cow's milk based infant formula bring the second choice infant feeding, formula, closer to the golden standard, exclusive breastfeeding.
