Role of brain tumor stem cells in tumor tissue remodeling

VernacularTitle:肿瘤组织重构:脑肿瘤干细胞的作用
Author: Yin-Yan WU ¹ ; Qiang HUANG ; DIAOYi ; Quan-Bin ZHANG ; Jun DONG ; Ai-Dong WANG ; Qing LAN
Author Information

1. 苏州大学附属第二医院
Keywords: Brain tumors; Stem cells; Xenografts; Tissue remodeling
From: Chinese Journal of Neuromedicine 2008;7(11):1124-1126
CountryChina
Language:Chinese
Abstract: Objective To investigate the origin of tumor cells and vascular endothelial cells in intraeranial brain tumor stem cell (BTSC) xenografls and elucidate the role of BTSCs in brain tumor tissue remodeling. Methods BTSC spheres were injected into the right candate nucleus of nude mice, and the mice were sacrificed after the occurrence ofcachexia to obtain the tumor tissue. Routine paraffin embedding, slicing, HE staining and human leucocyte antigen (HLA) staining of the tumor tissues were performed for observation of the tumor tissues under optical microscope. Results HE staining displayed dissemination growth of the tumor cells in the host brain tissue. HLA staining revealed the presence of blood vessels constituted directly by the tumor cells. Conclusion In the intracranial xenografts of BTSCs, the tumor cells are extensively distributed and constitute the blood vessels. The BTSCs play an important role in glioma tissue remodeling by differentiating into vascular endothelial cells in the tumors.